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Results for "

stimulator of interferon genes (STING)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	IFNAR (1) STING (24) Drug-Linker Conjugates for ADC (3) Endogenous Metabolite (2) Influenza Virus (1)
By Research Areas:	Cancer (20) Infection (2) Inflammation/Immunology (13)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Targets Recommended: STING IFNAR AIM2 Nuclear Factor of activated T Cells (NFAT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131994

STING agonist-16	STING	Infection Cancer
STING agonist-16 (1a) is a specific stimulator of interferon genes (STING) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool .

HY-12885A

ADU-S100 disodium salt Maximum Cited Publications 41 Publications Verification MIW815 disodium salt; ML RR-S2 CDA disodium salt
ADU-S100 disodium salt (MIW815 disodium salt) is an activator of stimulator of interferon genes (STING).

HY-151264

BSP16	STING	Cancer
BSP16 is a potent, orally active **stimulator of interferon genes (STING)** agonist. BSP16 can selectively stimulate the STING pathway. BSP16 can be used for the research of cancer .

HY-143321

STING agonist-13	STING	Cancer
STING agonist-13 is a stimulator of interferon genes (STING) agonist, for cancer immunity via STING-mediated immune activation. STING agonist-13 can stimulate *STING* downstream signaling and promoting type I interferon immune responses. STING agonist-13 significantly decreases tumor volume and shows immunological memory-derived cancer inhibition .

HY-139586

Ulevostinag MK-1454	STING	Cancer
Ulevostinag (MK-1454) is a potent cyclic dinucleotide agonist stimulator of interferon genes (STING). Ulevostinag (MK-1454) acts in the intra-tumoral route by targeting the stimulator of interferon genes (STING) protein. Ulevostinag (MK-1454) can be used for immuno-tumor cancer disease research .

HY-112921A

diABZI STING agonist-1 15+ Cited Publications	STING	Inflammation/Immunology
diABZI STING agonist-1 is a selective stimulator of interferon genes *(STING)* receptor agonist, with EC₅₀s of 130, 186 nM for human and mouse, respectively.

HY-112921B

diABZI STING agonist-1 trihydrochloride 15+ Cited Publications	STING	Inflammation/Immunology Cancer
diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes *(STING)* receptor agonist, with EC₅₀s of 130, 186 nM for human and mouse, respectively.

HY-130116

IACS-8779

STING Cancer

IACS-8779 is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy .

IACS-8779	STING	Cancer
IACS-8779 is a highly potent **stimulator of interferon genes (STING)** agonist with robust systemic antitumor efficacy .

HY-112921

diABZI STING agonist-1 (Tautomerism)	STING	Inflammation/Immunology
diABZI STING agonist-1 Tautomerism (compound 3) is a selective stimulator of interferon genes *(STING)* receptor agonist, with EC₅₀s of 130, 186 nM for human and mouse, respectively.

HY-138683

STING-IN-3 2 Publications Verification	STING	Inflammation/Immunology
STING-IN-3 is an inhibitor of **stimulator of interferon genes (STING)*. STING-IN-3 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING* .

HY-153987

STING agonist-33

Others Cancer

STING agonist-33 (example 1) is an agonist of STING (stimulator of interferon genes) based on 4-ethyl-2-methylthiazole-5-carboxylic acid ^{[1] ^.}

STING agonist-33	Others	Cancer
STING agonist-33 (example 1) is an agonist of STING (stimulator of interferon genes) based on 4-ethyl-2-methylthiazole-5-carboxylic acid ^{[1] ^.}

HY-12885

ADU-S100 MIW815; ML RR-S2 CDA	STING	Inflammation/Immunology Cancer
ADU-S100 (MIW815), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity .

HY-123943

STING agonist-4 4 Publications Verification	STING	Cancer
STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC₅₀) of 20 nM. STING agonist-4 is a two symmetry-related amidobenzimidazole (ABZI)-based compound to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function .

HY-12885B

ADU-S100 ammonium salt Maximum Cited Publications 41 Publications Verification MIW815 ammonium salt; ML RR-S2 CDA ammonium salt	STING	Inflammation/Immunology Cancer
ADU-S100 ammonium salt (MIW815 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity .

HY-12512

cGAMP 5+ Cited Publications Cyclic GMP-AMP; 3',3'-cGAMP	STING	Inflammation/Immunology
cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-139586C

Ulevostinag (isomer 3) MK-1454 (isomer 3)	STING	Cancer
Ulevostinag (isomer 3) (example 246) is a potent cyclic dinucleotide agonist stimulator of interferon genes (STING). Ulevostinag (isomer 3) plays an important role in anti-tumor research .

HY-110385

cGAMP disodium 5+ Cited Publications Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium	STING Endogenous Metabolite	Inflammation/Immunology
cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes *(STING), which activates a signaling cascade leading to the production of type I interferons* and other immune mediators .

HY-110385A

cGAMP diammonium 5+ Cited Publications Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium	STING Endogenous Metabolite	Inflammation/Immunology
cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes *(STING), which activates a signaling cascade leading to the production of type I interferons* and other immune mediators .

HY-12885C

ADU-S100 enantiomer ammonium salt MIW815 enantiomer ammonium salt; ML RR-S2 CDA enantiomer ammonium salt	Others	Inflammation/Immunology
ADU-S100 enantiomer ammonium salt (MIW815 enantiomer ammonium salt) is the less active enantiomer of ADU-S100. ADU-S100 is an activator of stimulator of interferon genes (STING) .

HY-152861

Dazostinag TAK-676 free base	STING	Cancer
Dazostinag (TAK-676 free base) is an agonist of **stimulator of interferon genes** (STING) protein with antineoplastic activity. Dazostinag can serve as a playload to synthesis antibody-drug conjugates (ADCs) .

HY-130116A

IACS-8779 disodium	STING	Cancer
IACS-8779 disodium is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy. IACS-8779 disodium shows robust activation of the STING pathway in vitro and a superior systemic anti-tumor response in the B16 murine model of melanoma .

HY-155100

BI 7446	STING	Inflammation/Immunology Cancer
BI 7446 is a cyclic dinucleotide (CDN)-based potent and selective stimulator of interferon genes (STING) agonist. BI 7446 can activate all five STING variants in cells and induce tumor-specific immune-mediated tumor rejection. BI 7446 can be used for immuno-oncology research .

HY-148346

STING agonist-20-Ala-amide-PEG2-C2-NH2	Drug-Linker Conjugates for ADC STING	Cancer
STING agonist-20-Ala-amide-PEG2-C2-NH2 is an active scaffold comprising a stimulator of interferon genes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used for the research of cancer .

HY-151513

Iso5-2DC18	Others	Cancer
Iso5-2DC18 is a lipid that can be used for the synthesis of amine containing lipids. These amine containing lipids can be used for mRNA delivery, activate the stimulator of interferon genes (STING) pathway, and exhibit anti-tumor immunity .

HY-155109

Antitumor agent-114	STING	Inflammation/Immunology Cancer
Antitumor agent-114 is a potent stimulator of interferon genes (STING) agonist. Antitumor agent-114 activates immunity and reduces tumor volume in a mouse model of breast cancer. Antitumor agent-114 can be used for immunity and cancer diseases research .

HY-148346A

STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA	Drug-Linker Conjugates for ADC STING	Cancer
STING agonist-20-Ala-amide-PEG2-C2-NH2 (Compound 30b) TFA is an active scaffold comprising a stimulator of interferon genes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used for the research of cancer .

HY-10964

Vadimezan 30+ Cited Publications DMXAA; ASA-404	STING IFNAR Influenza Virus	Infection Cancer
Vadimezan (DMXAA; ASA-404), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the **stimulator of interferon genes** (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan has anti-influenza virus H1N1-PR8 activities.

HY-141662

2',3'-cGAMP-C2-PPA	STING Drug-Linker Conjugates for ADC	Inflammation/Immunology Cancer
2’,3’-cGAMP-C2-PPA is a cyclic dinucleotide interferon gene-stimulating protein (STING) agonist. 2’,3’-cGAMP-C2-PPA is a drug conjugated conjugate used to target antibody-drug conjugated conjugate (ADC) for the treatment of cancer. 2’,3’-cGAMP-C2-PPA can be used in the study of immune and tumor-related diseases .

cGAMP disodium 5+ Cited Publications Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Endogenous Metabolite
cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes *(STING), which activates a signaling cascade leading to the production of type I interferons* and other immune mediators .

cGAMP diammonium 5+ Cited Publications Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium	Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology	STING Endogenous Metabolite
cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes *(STING), which activates a signaling cascade leading to the production of type I interferons* and other immune mediators .

Species:	Human (2) Mouse (1)
Tag:	SUMO (2) His (3)
Source:	E. coli Cell-free (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70700

	TMEM173 Protein, Human (Sumo-His) stimulator of interferon genes protein; TMEM173; Mediator of IRF3 activation; sting;	Human	E. coli
	The TMEM173 protein acts as a promoter of innate immune signaling, acting as a sensor of bacterial and viral cytoplasmic DNA, ultimately promoting the production of type I interferons (IFN-α and IFN-β). This innate immune response is triggered in response to the delivery of non-CpG double-stranded DNA from viruses and bacteria into the cytoplasm. TMEM173 Protein, Human (Sumo-His) is the recombinant human-derived TMEM173 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of TMEM173 Protein, Human (Sumo-His) is 187 a.a., with molecular weight of 35-38 kDa.

HY-P702453

	STING1 Protein, Mouse (Cell-Free, His) stimulator of interferon genes protein; Endoplasmic reticulum interferon stimulator; ERIS; Mediator of IRF3 activation; MMITA; Transmembrane protein 173	Mouse	E. coli Cell-free
	STING1 is a promoter of innate immune signaling, a key sensor of bacterial and viral cytoplasmic DNA, and promotes the production of type I interferons (IFN-α and IFN-β). This innate immune response is triggered in response to non-CpG double-stranded DNA delivered to the cytoplasm from various pathogens. STING1 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived STING1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of STING1 Protein, Mouse (Cell-Free, His) is 378 a.a., with molecular weight of 48.9 kDa.

HY-P70700A

	TMEM173 Protein, Human (N-Sumo-His) stimulator of interferon genes protein; TMEM173; Mediator of IRF3 activation; sting;	Human	E. coli
	The TMEM173 protein acts as a promoter of innate immune signaling, acting as a sensor of bacterial and viral cytoplasmic DNA, ultimately promoting the production of type I interferons (IFN-α and IFN-β). This innate immune response is triggered in response to the delivery of non-CpG double-stranded DNA from viruses and bacteria into the cytoplasm. TMEM173 Protein, Human (N-Sumo-His) is the recombinant human-derived TMEM173 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of TMEM173 Protein, Human (N-Sumo-His) is 187 a.a., with molecular weight of ~35.19 kDa.


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stimulator of interferon genes (STING)

Inhibitors & Agonists

NaturalProducts

Recombinant Proteins

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